Instinct Bio Moves GENRÊVER to a “Proof Before Promotion” Direct Model, Redirecting Advertising Spend to Customer Trials — Opens with “14 Days, ¥0” for GENRÊVER 001 Serum

TOKYO, October 19, 2026 — INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC. (Nasdaq: BIOT) ("Instinct Bio" or the "Company") today announced a change in how its GENRÊVER skincare brand reaches customers in Japan. Instead of spending on television commercials, advertising and paid social-media promotion, the Company will put that budget into letting customers use the product themselves. As the first initiative under this approach, its subsidiary INSTINCT BROTHERS Co., Ltd. will open applications for "14 Days, ¥0," which delivers GENRÊVER 001 serum free of charge to the first 100 applicants, at 7:00 a.m. Japan Standard Time on Tuesday, October 20, 2026. Highlights - Advertising budget redirected to the customer. Spending whose return cannot be measured is replaced with product in customers' hands. Product and shipping are free, and participants are never enrolled in a subscription automatically. - Made, recorded and sold within the Group. GENRÊVER 001 is formulated with high-quality ingredients held by the Group, including an ingredient developed in-house; it is manufactured by Group cosmetics manufacturer Artisans Production Co., Ltd. and sold through the Group's own online store, Value Village. - A verifiable record on every bottle. Manufacturing and shipping records are written to a blockchain, and anyone can view them by scanning the QR code on the bottle. - Designed to spread from person to person. From November 10, 2026, each participant can invite up to five family members or friends, allowing the first 100 participants to extend the trial to as many as 600 people. Why this approach Cosmetics have long been sold on the strength of advertising. Because the GENRÊVER business holds its ingredients, manufacturing, sales channel and traceability within the Group, the Company believes it can compete by putting its money into the product and the customer's own experience rather than into advertising. Participants record their skin with photos and notes on the day the product arrives (day 0), day 7 and day 14, and decide for themselves whether to continue. Customers who continue buy directly from the Group through Value Village. The Company intends to use what it learns from this program, including how many participants choose to continue, to guide how it develops the GENRÊVER business. Chairman's comment "We are not going to ask anyone to believe an advertisement," said Tomoki Nagano, Chairman and Chief Executive Officer of Instinct Bio. "We make this serum in our own factory, from ingredients we hold ourselves, and we record how every bottle was made. So we would rather invest in fourteen days of your own experience than in telling you how good it is. Use it, and decide for yourself. This is not a one-off promotion. It is how we intend to build GENRÊVER, and we are committed to it." Campaign overview - Product: GENRÊVER 001 serum (30 mL) - Eligible: the first 100 applicants (first-come, first-served; no lottery). Applications close once 100 places are filled. - Cost: product and shipping are both free. Delivery within Japan only, including Hokkaido, Okinawa and remote islands. No automatic subscription. - How it works: participants record their own skin with photos and notes on day 0, day 7 and day 14, and decide for themselves whether to continue. For those who continue, a bottle is ¥4,000 and a refill ¥3,200 (tax included, shipping extra). - How to apply: on the dedicated page of genrever.com, verify identity with a six-digit code sent by email, then complete a ¥0 checkout on Value Village. No payment information is required. - Invitations: from Tuesday, November 10, 2026, participants can invite up to five family members or friends. - Manufacturing and traceability: manufactured by Artisans Production Co., Ltd., a Group cosmetics manufacturer. Manufacturing and shipping records are written to a blockchain and can be viewed via the QR code on the bottle. Campaign page: https://genrever.com/001 About Instinct Bio INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC. (Nasdaq: BIOT) is a Tokyo-based, vertically integrated skincare and wellness group whose companies develop ingredients, manufacture products and sell them directly to customers. For more information, visit https://instinct-biot.com/. Forward-Looking Statements This announcement contains forward-looking statements, including statements about the Company's marketing approach, the expected scope of the program and how the Company intends to develop the GENRÊVER business. Words such as "will," "intend," "believe" and similar expressions identify forward-looking statements. These statements are based on current expectations and are subject to risks and uncertainties, including those described in the Company's filings with the U.S. Securities and Exchange Commission, that could cause actual results to differ materially. The Company undertakes no obligation to update any forward-looking statement except as required by law. Contact Instinct Bio Investor Relations — ir@instinct-bro.com