The thinking and the science behind BIOT.
CEO essays, evidence-based research and plain-language explainers — one structured hub covering how INSTINCT BIO thinks and what its science actually says.
The Book of Value
How does BIOT create value?
The official three-chapter series on value creation, the value chain, and the metrics behind the numbers.
How this hub is organised
174 published articles170 articles
CEO Essays
Personal essays by Tomoki Nagano, Chairman & CEO. These reflect the author's own perspective and are not official corporate disclosure unless explicitly stated.
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BIOT Research
Evidence-based educational and research content. Substantive scientific, medical, regulatory or market claims carry visible references.
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Explainers
Short, source-supported answers to high-value questions about BIOT and its science.
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CEO Essays
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Marie Curie — Eight Tons of Ore and a Patent Let Go
Marie Curie's life stacked every condition of "impossible": a woman born in Poland, barred from university at home; in Paris, the doors of science shut against her sex; denied a proper laboratory, she and Pierre worked in a leaky shed. In that shed she made the century's discovery — the unknown radioactive elements polonium and radium. To prove their existence she spent years boiling, stirring, and refining tons of ore residue with her own hands, extracting in the end a mere fraction of a gram.
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Van Gogh — One Painting Sold in His Lifetime
Vincent van Gogh lived as a painter for only ten years — committing at twenty-seven, dying at thirty-seven — leaving roughly two thousand oils and drawings. And in his lifetime, only one painting is reliably said to have sold. The market ignored him completely; the art establishment rejected him; his brother Theo's allowances sustained him to the end.
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Beethoven — He Wrote Joy With Ears That Could Not Hear
For a musician, hearing is life — and Ludwig van Beethoven began losing his in his late twenties. At thirty-one he wrote what is known as the Heiligenstadt Testament, a will engraved with the despair of a composer going deaf. At that suicidal depth, he did not break his pen; after the testament came the Eroica and the run of masterpieces that rewrote music.
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Abraham Lincoln — A Resume Full of Defeats
The early life of Abraham Lincoln, America's most beloved president, is told as a catalog of defeat: born in a log cabin with almost no formal schooling, failed in business, lost his love, suffered breakdown, lost legislative and congressional and senate races — the traditional list is partly exaggerated, historians note, but that his road was paved with losses is beyond dispute. Then, in 1860, at fifty- one, he won the presidency — into a nation splitting in two — fought through the worst war in its history, achieved emancipation, and at Gettysburg spoke of government of, by, and for the people. Had he won that senate seat, President Lincoln might never have existed; defeat kept pushing him toward the larger stage.
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CEO essays reflect the author's personal perspective. For verified corporate information, see verified corporate facts.
BIOT Research
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What does vertical integration mean in biotechnology?
Vertical integration means a single group owns consecutive stages of its value chain rather than buying them from third parties. In biotechnology that typically means research, materials sourcing, manufacturing, brand development and distribution sitting inside one corporate structure. The practical effect is control: one quality standard, traceability from material to finished lot, and faster iteration between research and product. It does not, by itself, make any product more effective, and it does not replace regulatory approval.
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What are exosomes? A plain-language explainer
Exosomes are small extracellular vesicles — membrane-bound particles roughly 30–150 nanometres across — that cells release to carry proteins, lipids and nucleic acids to other cells. Researchers study them as a mechanism of cell-to-cell signalling and as a possible delivery vehicle. The international standard for reporting such research is MISEV, published by the International Society for Extracellular Vesicles. In the United States, exosome products are not approved by the FDA for treating any condition, and the FDA has issued consumer warnings on unapproved exosome and stem cell products.
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What is BIOT? INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC., explained
BIOT is the Nasdaq ticker symbol of INSTINCT BIO TECHNICAL COMPANY HOLDINGS INC., a holding company incorporated in the Cayman Islands whose ordinary shares began trading on The Nasdaq Stock Market on 24 July 2026. Its operating businesses originate in Japan and span research and development, sourcing, manufacturing, regenerative medicine-related technologies, cosmetics, wellness and consumer brands. It is a separate legal entity from its operating subsidiaries, including INSTINCT BROTHERS.
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What are exosomes? A plain-language explainer
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