R&D
Research and development across ingredients, formulations, and applied biotechnology.
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BIOT Research·
Stem Cell Serum: The Science Behind Culture Supernatants
A "stem cell serum" almost never contains stem cells. It contains culture supernatant — the liquid left after cells have been cultured and removed — which carries growth factors, cytokines and extracellular vesicles. Quality depends on cell origin, culture conditions, purification and stability in the finished formulation. This page is educational and makes no medical claim about any BIOT product.
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What does vertical integration mean in biotechnology?
Vertical integration means a single group owns consecutive stages of its value chain rather than buying them from third parties. In biotechnology that typically means research, materials sourcing, manufacturing, brand development and distribution sitting inside one corporate structure. The practical effect is control: one quality standard, traceability from material to finished lot, and faster iteration between research and product. It does not, by itself, make any product more effective, and it does not replace regulatory approval.
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From a Perfume-Loving Teenager to a Cosmetics Chairman
I loved perfume as a high schooler — just a simple "like," with no career calculation. Yet when I job-hunted after Canada, I chose a perfume maker from six offers, because I wanted to work near what I loved. The product development I learned there opened the door to a TSE-listed company, then to my own cosmetics business, and now forms the foundation of BIOT.
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What I Learned at a Tokyo Stock Exchange Company
My product development experience earned me a place at a company listed on the First Section of the Tokyo Stock Exchange. There I saw a world that runs not on individual hustle but on systems — for quality, approval, responsibility. But once I ran my own company, I understood: a company without systems dies when its founder falls.
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Why Celebrating in Advance Starts the Brain's Engine — The Science of Yoshuku
Let me examine our practice of yoshuku — celebrating in advance — from the brain's side. Honestly: "dream it and it comes true" is not supported by science; research reports that merely fantasizing about achievement can trick the brain into feeling it already has the prize, draining energy for action. Studies suggest those who vividly picture the desired future and squarely face present obstacles — psychologists call it mental contrasting — act the most.
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Dopamine Fires on Approach, Not Arrival — The True Nature of Excitement
Research on dopamine, the brain chemical deeply tied to drive, reports a crucial property: it works more strongly while approaching an anticipated reward than at the moment of receiving it. The brain burns hottest not when it has obtained, but while it feels itself closing in. This matches my fifty years of experience exactly — the days running toward our listing were hotter than the listing day itself.
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Smiles Are Contagious — A Leader's Face Is a Corporate Asset
"If I am not smiling, no one around me will smile" — my conviction apparently has scientific backing. Psychology has long studied emotional contagion: people unconsciously mirror the expressions and vocal tones before them, and the mirrored expression moves their own emotions in turn. The facial feedback effect — we don't only smile because we're happy; smiling can nudge happiness — has been studied for decades.
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What Changes When You Write "Thank You" — The Research on Gratitude
On gratitude, psychology has a famous family of experiments: some participants list things they are grateful for each week, others record hassles or mere events, and weeks later the groups are compared — with the gratitude writers reporting greater well-being and optimism. From writing alone, while circumstances changed not at all. The explanation is thought to lie in attention: the brain defaults to scanning for danger and lack, a useful survival habit, and a gratitude practice forces a weekly scan of what one already has and has received.
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The Brain Cannot Leave a Question Alone — Why This Series Ends the Same Way
Let me reveal why every installment ends with the same question. Psychology reports that the unfinished stays in memory: completed tasks are forgotten, while interrupted tasks and unanswered questions linger — the classic observation known as the Zeigarnik effect. Studies also suggest that being asked a question makes people begin observing themselves along its lines, sometimes changing behavior itself.
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Writing Orders the Mind — The Science Behind Management by Essay
When our executives wrote their life essays, one said: "I finally organized what my life has been." That sense of writing-as-organizing has a research pedigree. Psychology has long studied the effects of repeatedly writing about one's own significant experiences; a well-known line of studies reports beneficial changes in people who wrote for some minutes daily across several days. Writing gives swirling events the shape of a story — with a beginning and an end — and a shaped experience leaves the whirlpool of rumination and settles onto a shelf.
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Does Believing You Can Change Actually Change You? — On Mindset
Does believing "I can change" actually help? Educational psychology holds a famous lineage of research: children with a growth mindset — believing ability can be developed — were reported to persist at hard tasks, learn from failure, and improve over time. The size of the effect remains under active scrutiny, but one point recurs: the interpretation of failure determines the next action.
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Environment Builds the Brain — On Standing Somewhere Slightly Higher
Behavioral science repeatedly shows that human behavior is shaped less by individual resolve than by surrounding environments and relationships. Famous research reported that obesity, smoking, even happiness tend to spread through social ties; the standards around you quietly rewrite your "normal" — income, learning, appetite for challenge, all pulled toward the average of those you keep company with. One executive's essay is a living specimen: thrown among the prefecture's best as a freshman, he hyperventilated, clung on, and in six months owned a different body; at twenty-five, another stepped among adults who worked with joy, and his life began to change.
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Habit Beats Will — The Science of Stacking Small
How long until a new behavior automates into habit? Habit-formation research reports an average of around two months — sometimes half a year or more depending on the person and behavior. Quitting after three days is not weak will; it is passing judgment before automation could occur.
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The Mechanics of Attraction — Expectation, Attention, Action, Result
Asked whether I believe in the law of attraction, I answered: not as magic — but as a mechanism, with conviction. In a classic study, merely giving teachers the expectation that certain children would bloom was followed by those children's actual improvement — expectation changes treatment, treatment changes people, prophecy becomes fact. The brain discards torrents of information every second, keeping what you are searching for — buy a new car and the streets suddenly fill with the same model.
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What "Thank You" Does to the Body — The Physiology of Connection
I have written of gratitude as a habit of mind; here, what it does between people. Research identifies hormones involved in human bonding — rising in moments of trusted touch and cooperation, supporting security and connection — and saying or receiving "thank you" may be one of daily life's easiest switches for that circuitry. A further delight: studies comparing people who spent money on themselves versus on others reported higher happiness among the givers.
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When the Face in the Mirror Changes, the Heart Changes — The Psychology of Beauty
We are a beauty company, so we owe an answer to this question: what do cosmetics actually change? The skin's condition, of course — but psychology suggests something beyond. Research known as enclothed cognition reported that what we wear influences attention and behavior; likewise, many people repeatedly report feeling more confident and sociable on days they wear makeup.
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Connection Is Health — The Science of Companions Who Rejoice Together
This half of Season 1.5 closes by grounding our philosophy — "cherish the companions who rejoice together" — in the science of health. A famous research synthesis integrating data on hundreds of thousands of people compared predictors of long-term health and longevity and reported that the richness of social connection was among the strongest, with loneliness argued to rival widely known lifestyle risks. The director of a celebrated decades-long study of adult life concluded that what most determines happiness and health is neither wealth nor fame, but good relationships.
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The Brain Writes While You Sleep — Sleep and Memory
The next ten essays are original pieces in which I retell what brain science has shown in my own language as a manager and a man. Neuroscience reports that memory is consolidated not at the moment of learning but during sleep: the sleeping brain replays the day, moves what matters onto long-term shelves, and discards the rest. Learning does not end at the desk; it is completed in bed.
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Ideas Arrive When You Walk — Movement and the Brain
Good ideas do not arrive at the desk; they arrive while walking — and that is not merely a feeling. The effect of exercise on the brain is among the most active research areas of recent years: aerobic activity is reported to enhance factors supporting the growth and survival of neurons, with benefits for memory-related regions, mood stability and concentration, and experiments have reported broader idea generation while walking. Until I left for Canada at eighteen I was nothing but an athlete; I could not study, but I never stopped moving my body — and perhaps those years built the foundation of my brain.
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Words Reset the Brain — The Science of Self-Talk
We talk to ourselves all day long, and the quality of those words decides our state. Psychology studies self-talk: addressing oneself by name or as "you" rather than "I" is reported to create distance from emotion, improving composure and performance under pressure. Distance alone changes how the brain handles the moment.
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One Breath Switches the Body — The Physiology of Tension
Before any big moment I do exactly one thing: exhale slowly and long. Research on the autonomic nervous system shows that inhaling and exhaling shift heart rate and bodily state; a slow, extended exhale is reported to support the calming side of the system. When tension shortens the breath, the body concludes "danger" and thinking narrows; deliberately lengthening the breath sends the opposite signal from body to brain.
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We Become Whom We Watch — Mirror Neurons and Leading by Back
That showing beats telling is not mere folk wisdom; it is partly a matter of how the brain is built. Neuroscience has reported neurons that respond while watching another's action much as they do when performing it — the mirror neuron system. Its scope is debated, but the direction, that people trace inwardly what they see, is supported by much research and by daily experience.
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We Grow Strong Because We Laugh — Laughter and Stress
When I say we exist to increase the world's total volume of smiles, it is not a sentimental slogan; laughter does measurable work in the body. Studies report lower indicators of stress-related hormones in states of laughter and positive emotion, along with changes in pain perception and immune markers. The magnitude and conditions remain carefully debated, but the direction — that laughter moves bodily state — is widely supported.
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Name the Fear and It Shrinks — On the Amygdala
Becoming the chairman of a listed company does not remove anxiety. Because it does not, I learned how to handle it. Neuroscience reports that attaching verbal labels to emotion is accompanied by reduced activity in the amygdala, the region tied to fear and anxiety — a phenomenon called affect labeling.
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Meaning Over Reward — The Research on Intrinsic Motivation
My answer: raise it, yes — but pay alone is not enough. Psychology has reported that adding external rewards to behavior people already enjoy can reduce the motivation welling up from within, and a widely known framework holds that sustained effort requires a sense of deciding for oneself (autonomy), of getting better (mastery), and of doing something that matters (purpose). I have watched this on the floor for decades: at the same salary, the person who is trusted with a decision grows; at the same task, the person who knows whom it is for endures.
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The Brain Can Change at Any Age — Plasticity as Hope
Season 1.5 closes with the one line I most want to leave: the brain can change at any age. It was once believed that adult brains were fixed. Neuroscience has repeatedly shown otherwise — neuroplasticity, the continual remaking of neural connections through experience and learning.
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